Rome: Total War could be considered to be one of the most moddable PC games around because of the ease with which its text files and its units' skins can be edited. This has led to the creation of many modifications or "mods" made for Rome: Total War. Some of them change the game's units' skins and the game's campaign map to make it more realistic. Others still move the game's focus to a different time and place. Examples include:
- Europa Barbarorum, a modification designed to be a definitive, historically accurate, full conversion of Rome: Total War.
- Rome: Total Realism, a modification which aims toward a much more realistic and historically accurate Rome: Total War. Many new units, more historically accurate rosters and an extended map make it one of the most popular mods made for the game.